CU-CPTdos2 was used due to the fact source TLR2-antagonist
Physical recognition
To explore the activity of the synthesized and selected compounds 1 to 6 and 9 to 11 on the TLR2 activity, reporter cells overexpressing hTLR2 were used. 7, 10a, 11 Except for 1, all selected compounds decreased TLR2-mediated NF-?B activation in a primary screen (Figure step 3A). Additionally, cuatro, 6, 9 and 10 reduced Pam3CSK4-induced TLR2/1 responses to less than 40 % at fifty ?M and 2–6, 9 and 10 diminished Pam2CSK4-induced TLR2/6 responses to less than 50 % at 50 ?Mpound 6 and 11 abrogated the TLR2 response of both heterodimers almost completely and therefore showed a similar TLR2 inhibition as CU-CPT22 (Figure 3A). Leer más